Potential Inhibitors Targeting Papain-Like Protease of SARS-CoV-2: Two Birds With One Stone

Potential Inhibitors Targeting Papain-Like Protease of SARS-CoV-2: Two Birds With One Stone

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Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), the pathogen of the Coronavirus disease-19 (COVID-19), is still devastating the world causing significant chaos to the international community and posing a significant threat to global health.Since the first outbreak in late 2019, several lines of intervention have been developed to prevent the Using Baidu index to nowcast hand-foot-mouth disease in China: a meta learning approach spread of this virus.Nowadays, some vaccines have been approved and extensively administered.However, the fact that SARS-CoV-2 rapidly mutates makes the efficacy and safety of this approach constantly under debate.

Therefore, antivirals are still needed to combat the infection of SARS-CoV-2.Papain-like protease (PLpro) of SARS-CoV-2 supports viral reproduction and suppresses the innate immune response of the host, which makes PLpro an attractive pharmaceutical target.Inhibition of PLpro could not only prevent viral replication but also restore the antiviral immunity of the host, resulting in the speedy recovery of the patient.In this review, we describe structural and functional features on PLpro of SARS-CoV-2 and the latest development The Advances of Single-Cell RNA-Seq in Kidney Immunology in searching for PLpro inhibitors.

Currently available inhibitors targeting PLpro as well as their structural basis are also summarized.